UCLA Program in Global Health



	Research Education and Training Policy China Malawi Peru South Africa Uganda United States

	Countries China Malawi Peru South Africa Project Accept M•A•C Leadership Uganda United States Programs Research Education and Training Policy	Project Accept A Phase III Randomized Controlled Trial of Community Mobilization, Mobile Testing, Same-Day Results, and Post-Test Support for HIV in Sub-Saharan Africa and Thailand Project Accept is an HIV prevention trial in which 34 communities in Africa (in South Africa, Tanzania, and Zimbabwe) and 14 communities in Thailand are being randomized to receive either a community-based HIV voluntary counseling and testing (CBVCT) intervention plus standard clinic-based VCT (SVCT), or SVCT alone. The CBVCT intervention has three major strategies: (1) to make VCT more available in community settings; (2) to engage the community through outreach; and (3) to provide post-test support. These strategies are designed to change community norms and reduce risk for HIV infection among all community members, irrespective of whether they participated directly in the intervention. A community-level intervention based on modifying community norms can change the environmental context in which people make decisions about HIV risk, and has the potential to alter the course of the HIV epidemic in developing countries. This is the first international randomized controlled Phase III trial to determine the efficacy of a behavioral/social science intervention with an HIV incidence endpoint. Project Accept is funded as a National Institute of Mental Health (NIMH) Cooperative Agreement (grants 5U01MH066687, 5U01MH066688, 5U01MH066701, and 5U01MH066702) involving the NIMH and several U.S. and international institutions. The HIV Prevention Trials Network (HPTN) is also providing support to the project (HPTN 043)); support has also been provided by the Office of AIDS Research of the National Institutes of Health. The entire study, from planning work through data analysis, is scheduled to last 8 years. The intervention component of the study will last 3 years. Research funding and planning began in October of 2003; the study is scheduled to continue through 2011. UCLA serves as the multi-site coordinating center for Project Accept, and partners with sites in Soweto and Vulindlela, South Africa. Study Summary & Protocol Download a 3-page study summary. (PDF, 33K) Download the full study protocol. (PDF, 534K) Compendium of study materials Manuals, Instruments, etc. Study Publications Mobile VCT: Reaching Men and Young People in Urban and Rural South African Pilot Studies (NIMH Project Accept, HPTN 043) van Rooyen H, McGrath N, Chirowodza A, Joseph P, Fiamma A, Gray G, Richter L, Coates T. AIDS Behav. 2012 Nov 11. [Epub ahead of print] Health diplomacy and adapting global health interventions to local needs: findings from project accept (HPTN 043), a community-based intervention to reduce HIV incidence in populations at risk in Sub-Saharan Africa and Thailand Kevany S, Khumalo-Sakutukwa G, Murima O, Chingono A, Modiba P, Gray G, Van Rooyen H, Mrumbi K, Mbwambo J, Kawichai S, Chariyalertsak S, Chariyalertsak C, Paradza E, Mulawa M, Morin SF. BMC Public Health. 2012 Jun 20;12(1):459. [Epub ahead of print] Socio-economic status and health care utilization in rural Zimbabwe: Findings from Project Accept (HPTN 043) Kevany S, Sweat M, Singh B, Kulich M, Woelk G. Journal of Public Health in Africa. 2012;3(1):46-51. NIMH Project Accept (HPTN 043) HIV/AIDS Community Mobilization (CM) to Promote Mobile HIV Voluntary Counseling and Testing (MVCT) in Rural Communities in Northern Thailand: Modifications by Experience Kawichai S, Celentano D, Srithanaviboonchai K, Wichajarn M, Pancharoen K, Chariyalertsak C, Visrutaratana S, Khumalo-Sakutukwa G, Sweat M, Chariyalertsak S; and The Project Accept Study Team. AIDS Behav. 2011 Dec 15. [Epub ahead of print] Use of a High Resolution Melting (HRM) Assay to Compare gag, pol, and env Diversity in Adults with Different Stages of HIV Infection Cousins MM, Laeyendecker O, Beauchamp G, Brookmeyer R, Towler WI, Hudelson SE, Khaki L, Koblin B, Chesney M, Moore RD, Kelen GD, Coates T, Celum C, Buchbinder SP, Seage GR III, Quinn TC, Donnell D, Eshleman SH.PLoS ONE. 2011;6(11):e27211. HIV Surveillance in a Large, Community-Based Study: Results from the Pilot Study of Project Accept (HIV Prevention Trials Network 043) Piwowar-Manning E, Fiamma A, Laeyendecker O, Kulich M, Donnell D, Szekeres G, Robins-Morris L, Mullis CE, Vallari A, Hackett J Jr, Mastro TD, Gray G, Richter L, Alexandre MW, Chariyalertsak S, Chingono A, Sweat M, Coates T, Eshleman SH. BMC Infect Dis. 2011 Sep 24;11:251. No "Magic Bullet": Exploring Community Mobilization Strategies Used in a Multi-site Community Based Randomized Controlled Trial: Project Accept (HPTN 043) Tedrow VA, Zelaya CE, Kennedy CE, Morin SF, Khumalo-Sakutukwa G, Sweat MD, Celentano DD. AIDS Behav. 2011 Aug 6. [Epub ahead of print] The influence of antiretroviral treatment on willingness to test: a qualitative study in rural KwaZulu-Natal, South Africa Phakathi Z, Van Rooyen H, Fritz K, Richter L. African Journal of AIDS Research. 2011;10:2,173-180. Community-based intervention to increase HIV testing and case detection in people aged 16-32 years in Tanzania, Zimbabwe, and Thailand (NIMH Project Accept, HPTN 043): a randomised study Sweat M, Morin S, Celentano D, Mulawa M, Singh B, Mbwambo J, Kawichai S, Chingono A, Khumalo-Sakutukwa G, Gray G, Richter L, Kulich M, Sadowski A, Coates T; the Project Accept study team. Lancet Infect Dis. 2011 May 3. [Epub ahead of print]. Looking into the Future; South Africa men and women negotioating HIV risk and relationship intimacy (Project Accept/HPTN 043) Mindry D, Maman S, Chirowodza A, Muravha T, van Rooyen H, Coates T. Cult Health Sex. 2011 May;13(5):589-602. Who gets tested for HIV in a South African urban township? Implications for test and treat and gender-based prevention interventions Venkatesh KK, Madiba P, De Bruyn G, Lurie MN, Coates TJ, Gray GE. J Acquir Immune Defic Syndr. 2011 Feb 1;56(2):151-65. Recent HIV Type 1 Infection Among Participants in a Same-Day Mobile Testing Pilot Study in Zimbabwe Truong HH, Fritz K, McFarland W, Hartogensis W, Fiamma A, Coates TJ, Morin SF. AIDS Res Hum Retroviruses. 2011 Jan 15. [Epub ahead of print]. HIV-Related Stigma, Social Norms, and HIV Testing in Soweto and Vulindlela, South Africa: National Institutes of Mental Health Project Accept (HPTN 043) Young SD, Hlavka Z, Modiba P, Gray G, Van Rooyen H, Richter L, Szekeres G, Coates T. J Acquir Immune Defic Syndr. 2010 Oct 27;55:62-624. Recruiting heterosexual couples from the general population for studies in rural South Africa--challenges and lessons (Project Accept, HPTN 043) McGrath N, Hosegood V, Chirowodza A, Joseph P, Darbes L, Boettiger M, van Rooyen H. S Afr Med J. 2010 Oct 1;100(10):658, 660. Can HIV incidence testing be used for evaluating HIV intervention programs? A reanalysis of the Orange Farm male circumcision trial (ANRS-1265) Fiamma A, Lissouba P, Amy OE, Singh B, Laeyendecker O, Quinn TC, Taljaard D, Auvert B. BMC Infect Dis. 2010 May 27;10:137. Awareness about antiretroviral treatment, intentions to use condoms, and decisions to have an HIV test among rural Northern Lowland Thai and ethnic minority young adults Srithanaviboonchai K, Celentano DD, Visaruratana S, Kawichai S, Wichajarn M, Genberg B, Chariyalertsak C, Kulich M, Chariyalertsak S. Asia Pac J Public Health. 2010 Apr;22(2):212-8. Keep talking about it: HIV/AIDS-related communication and prior HIV testing in Tanzania, Zimbabwe, South Africa, and Thailand Hendriksen ES, Hlubinka D, Chariyalertsak S, Chingono A, Gray G, Mbwambo J, Richter L, Kulich M, Coates TJ. AIDS Behav. 2009 Dec;13(6):1213-21. Using Participatory Mapping to Inform a Community-Randomized Trial of HIV Counseling and Testing Maman S, Lane T, Ntogwisangu J, Modiba P, Vanrooyen H, Timbe A, Visrutaratna S, Fritz K. Field Methods. 2009 Nov;21:368-387. Epub 2009 July 28. Only skin deep: Limitations of public health understanding of male circumcision in South Africa Sithole B, Mbhele L, Rooyen HV, Khumalo-Sakutukwa G, Richter L. SAMJ. Sep 2009; 99(9). A comparison of HIV/AIDS-related stigma in four countries: negative attitudes and perceived acts of discrimination towards people living with HIV/AIDS Genberg BL, Hlavka Z, Konda KA, Maman S, Chariyalertsak S, Chingono A, Mbwambo J, Modiba P, Van Rooyen H, Celentano DD. Soc Sci Med. 2009 Jun;68(12):2279-87. Epub 2009 May 7. A comparison of HIV stigma and discrimination in five international sites: the influence of care and treatment resources in high prevalence settings Maman S, Abler L, Parker L, Lane T, Chirowodza A, Ntogwisangu J, Srirak N, Modiba P, Murima O, Fritz K. Soc Sci Med. 2009 Jun;68(12):2271-8. Epub 2009 Apr 23. Test and tell: correlates and consequences of testing and disclosure of HIV status in South Africa (HPTN 043 Project Accept) Wong LH, Rooyen HV, Modiba P, Richter L, Gray G, McIntyre JA, Schetter CD, Coates T. J Acquir Immune Defic Syndr. 2009 Feb 1;50(2):215-22. Using Community Ethnography and Geographical Information Systems in a Community Based Intervention Trial in Vulindlela, South Africa (Project Accept-HPTN 043) Chirowodza AC, Sikotoyi SV, Joseph P, van Rooyen H, Richter L, Coates TJ. Journal of Community Psychology. 2009;37(1):41-57. Project Accept (HPTN 043): a community-based intervention to reduce HIV incidence in populations at risk for HIV in sub-Saharan Africa and Thailand Khumalo-Sakutukwa G, Morin SF, Fritz K, Charlebois ED, van Rooyen H, Chingono A, Modiba P, Mrumbi K, Visrutaratna S, Singh B, Sweat M, Celentano DD, Coates TJ; NIMH Project Accept Study Team. J Acquir Immune Defic Syndr. 2008 Dec 1;49(4):422-31. HIV risk behaviors in sub-Saharan Africa and Northern Thailand: baseline behavioral data from Project Accept Genberg BL, Kulich M, Kawichai S, Modiba P, Chingono A, Kilonzo GP, Richter L, Pettifor A, Sweat M, Celentano DD; NIMH Project Accept Study Team (HPTN 043). J Acquir Immune Defic Syndr. 2008 Nov 1;49(3):309-19. Assessing HIV/AIDS stigma and discrimination in developing countries Genberg BL, Kawichai S, Chingono A, Sendah M, Chariyalertsak S, Konda KA, Celentano DD. AIDS Behav. 2008 Sep;12(5):772-80. Epub 2007 Dec 13. Behavioural strategies to reduce HIV transmission: how to make them work better Coates TJ, Richter L, Caceres C. Lancet. 2008 Aug 23;372(9639):669-84. Epub 2008 Aug 5. Balancing science and community concerns in resource-limited settings: Project Accept in rural Zimbabwe Chingono A, Lane T, Chitumba A, Kulich M, Morin S. Clin Trials. 2008;5(3):273-6. Community-based Voluntary Counseling and Testing Services in Rural Communities of Chiang Mai Province, Northern Thailand Kawichai S, Celentano DD, Chariyalertsak S, Visrutaratna S, Short O, Cholticha Ruangyuttikarn C, Chariyalertsak C, Genberg B, Beyrer B. AIDS Behav. 2007 May 15; [Epub ahead of print]. (PDF, 159K) Removing Barriers to Knowing HIV Status: Same-Day Mobile HIV Testing in Zimbabwe Morin SF, Khumalo-Sakutukwa G, Charlebois ED, Routh J, Fritz K, Lane T, Vaki T, Fiamma A, Coates TJ. J Acquir Immune Defic Syndr. 2006 Feb 1;41(2):218-224. (PDF, 86K) HIV Voluntary Counseling and Testing and HIV Incidence in Male Injecting Drug Users in Northern Thailand: Evidence of an Urgent Need for HIV Prevention Kawichai S, Celentano DD, Vongchak T, Beyrer C, Suriyanon V, Razak MH, Srirak N, Rungruengthanakit K, Jittiwutikarn J. J Acquir Immune Defic Syndr. 2006 Feb 1;41(2):186-193. (PDF, 94K) Contact Information Please direct all correspondence, questions, and press inquiries related to the study to: Greg Szekeres UCLA Program in Global Health 9911 West Pico Blvd., Suite 955 Los Angeles, CA 90035-2703 U.S.A. Phone: +1-310-557-3044 Fax: +1-310-557-3679 Email: gszekeres@mednet.ucla.edu
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